Is Ozempic, Wegovy a Ticking Time Bomb for Mental Health?

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Recent research has investigated the potential link between glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, and suicidal ideation. While some studies have suggested a possible association, others have found no such connection.

A study published in JAMA Network Open in August 2023 reported an increased risk of suicidal ideation associated with semaglutide use. However, a subsequent study published in JAMA Internal Medicine in September 2023 found no such link.

Another study, published in Nature Medicine in January 2024, examined a real-world cohort of over 240,000 individuals with overweight or obesity and found no association between semaglutide use and suicidal ideation.

GLP-1 agonists, including semaglutide, have revolutionized obesity treatment. However, concerns have been raised about their potential side effects, including psychiatric symptoms.

The European Medicines Agency (EMA) is currently reviewing data on the risk of suicidal thoughts and self-harm associated with GLP-1 receptor agonists.

Experts emphasize the need for caution and further research to fully understand the potential link between semaglutide and suicidal ideation.

Individuals taking GLP-1 agonists should be closely monitored for any changes in mood or behavior. If you experience suicidal thoughts or feelings, seek immediate medical attention.